반응 #72737

반응 방정식

(−)-5-(2-bromopyrid-5-yl)-1-azabicyclo[3.2.1]octane

n-butyllithium

1-(dimethylaminosulfonyl)imidazole

sodium hydroxide

→

(−)-5-[2-(−1H-Imidazol-2-yl)pyrid-5-yl]-1-azabicyclo[3.2.1]octane

용매

hexane

tetrahydrofuran

chloroform

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.ADDITIONis introduced into a 25 ml three-necked flask
2. 2
   workup.ADDITIONis then added
3. 3
   기타to return to 20° C.
4. 4
   workup.ADDITIONare then successively added
5. 5
   온도The mixture is then refluxed for 24 hours
6. 6
   온도cooled to room temperature
7. 7
   추출The aqueous phase is extracted with chloroform
8. 8
   세척the combined organic phases are then washed with saturated aqueous sodium chloride solution
9. 9
   건조dried over sodium sulfate
10. 10
    여과filtered
11. 11
    농축concentrated under reduced pressure
12. 12
    기타The residue is purified by chromatography on a column of silica gel
13. 13
    세척eluting with a mixture of chloroform, methanol and aqueous ammonia in 95/5/0.5 proportions
14. 14
    기타is used in the following step without further purification

실험 절차

1 g (5.7 mmol) of 1-(dimethylaminosulfonyl)imidazole dissolved in 9 ml of tetrahydrofuran is introduced into a 25 ml three-necked flask. The reaction medium is cooled to −78° C. and 4 ml of a 1.6M solution of n-butyllithium in hexane is added dropwise over 20 minutes. 0.73 g (5.4 mmol) of zinc chloride dissolved in 4 ml of tetrahydrofuran is then added. The mixture is stirred while allowing the temperature to return to 20° C., and 1.5 g (11.1 mmol) of zinc chloride, 0.1 g (0.09 mmol) of tetrakis(triphenylphosphine)palladium and 0.56 g (2.1 mmol) of (−)-5-(2-bromopyrid-5-yl)-1-azabicyclo[3.2.1]octane (prepared according to the method described in step 1.2 of Example 1), dissolved in 5 ml of tetrahydrofuran, are then successively added. The mixture is then refluxed for 24 hours and then cooled to room temperature. 30 ml of aqueous 30% sodium hydroxide solution and 50 ml of chloroform are added. The aqueous phase is extracted with chloroform and the combined organic phases are then washed with saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue is purified by chromatography on a column of silica gel, eluting with a mixture of chloroform, methanol and aqueous ammonia in 95/5/0.5 proportions and is used in the following step without further purification.

출처