반응 #727264

반응 방정식

(4-(pyridin-2-yloxymethyl)-phenyl)methanol

→

title compound

수율 42.0%

4-(Pyridin-2-yloxymethyl)-benzaldehyde

수율 42.0%

용매

methylene chloride

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered through a Celite pad
2. 2
   기타the solvent was evaporated under a reduced pressure
3. 3
   기타The residue was purified by silica gel column chromatography (ethyl acetate:heptane=1:4)

실험 절차

To a mixture of (4-(pyridin-2-yloxymethyl)-phenyl)methanol (1.9 g, 8.6 mmol) described in Manufacturing Example 2-1-1 and methylene chloride (30 mL) was added manganese dioxide (15 g, 17 mmol) at room temperature, which was stirred overnight at that temperature. The reaction mixture was filtered through a Celite pad, and the solvent was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:heptane=1:4) to obtain the title compound (770 mg, 42%).

출처