반응 #72710

반응 방정식

water

o-aminobenzoate

benzaldehyde

sodium hydrogen sulfite

dimethylacetamide

→

desired product

수율 85.0%

2-Phenyl-quinazolin-4-ol

수율 85.0%

반응 조건

후처리

1. 1
   온도was heated
2. 2
   기타A precipitate was formed
3. 3
   기타collected
4. 4
   기타dried

실험 절차

A mixture of o-aminobenzoate (7 mmol), benzaldehyde (7 mmol) and sodium hydrogen sulfite (10.5 mmol) in dimethylacetamide (10 ml) was heated with stirring at 150° C. overnight. Then, the reaction mixture was poured into water (300 ml). A precipitate was formed, collected and dried. Recristallization from benzene gave the desired product in 85% yield.

출처