반응 #726680

반응 방정식

2-ethyl-1-butanol

triethylenediamine

p-toluenesulfonyl chloride

→

title compound

수율 95.6%

Toluene-4-sulfonic acid 2-ethylbutyl ester

수율 95.6%

용매

DCM

DCM

반응 조건

후처리

1. 1
   추출extracted with 1.0N NaOH (2×40 mL)
2. 2
   기타The organic layer was collected
3. 3
   건조dried over anhydrous sodium sulfate
4. 4
   여과filtered
5. 5
   기타isolated by rotary evaporation

실험 절차

To a solution of 2-ethyl-1-butanol (1.00 g, 9.79 mmol), triethylenediamine (1.32 g, 11.7 mmol) in DCM (30 mL, 0.5 mol) cooled to 0° C. was added p-toluenesulfonyl chloride (1.96 g, 10.3 mmol) in DCM (10 mL) The reaction mixture was stirred for 30 min, and extracted with 1.0N NaOH (2×40 mL). The organic layer was collected, dried over anhydrous sodium sulfate, filtered, and isolated by rotary evaporation to give the title compound (2.40 g).

출처