반응 #72650

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2-chloroquinazolin-4-amine

2-Chloroquinazolin-4-amine

hydrazine

→

title compound

수율 86.0%

2-Hydrazinylquinazolin-4-amine

수율 86.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도After the reaction mixture was cooled down
2. 2
   여과the resulting precipitate was collected by filtration
3. 3
   세척rinsed with ethanol
4. 4
   기타dried in the air

실험 절차

A mixture of 2-chloroquinazolin-4-amine (Example 38) (100 mg, 0.56 mmol) and hydrazine (0.09 mL, 2.79 mmol) in ethanol (5 mL) was heated in a sealed tube at 80° C. overnight. After the reaction mixture was cooled down, the resulting precipitate was collected by filtration, rinsed with ethanol and dried in the air to give the title compound (84 mg, 86%). 1H NMR (400 MHz, DMSO-d6) δ4.2 (bs, 2H), 4.6 (bs, 2H), 7.0 (t, J=7.2 Hz, 1H), 7.27 (d, J=8.0 Hz, 1H), 7.43 (s, 1H), 7.61 (s, 1H), 7.87 (d, J=7.6 Hz, 1H).

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