반응 #72647

반응 방정식

2,4-dichloroquinazoline

ammonia

→

title compound

수율 72.0%

2-Chloroquinazolin-4-amine

수율 72.0%

용매

EtOAc

THF

반응 조건

후처리

1. 1
   세척washed with saturated NaHCO3, water and brine
2. 2
   건조dried over Na2SO4
3. 3
   여과filtered
4. 4
   기타evaporated
5. 5
   세척The resulting solid was washed with EtOAc

실험 절차

To a solution of 2,4-dichloroquinazoline (2.0 g, 10 mmol) in THF (10 mL), was added ammonia (28-30% in water, 18 mL). The reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with EtOAc, washed with saturated NaHCO3, water and brine, dried over Na2SO4, filtered and evaporated. The resulting solid was washed with EtOAc to give the title compound (1.3 g, 72%). 1H NMR (400 MHz, DMSO-d6) δ7.52-7.48 (m, 1H), 7.6-7.58 (m, 1H), 7.8-7.76 (m, 1H), 8.22-8.20 (m, 1H), 8.32 (bs, 2H).

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