반응 #726258

반응 방정식

phenylmethyl[((3S)-1-{(2S)-2-hydroxy-2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]carbamate

→

title compound

수율 98.0%

(1S)-2-[(3S)-3-(aminomethyl)-1-pyrrolidinyl]-1-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethanol

수율 98.0%

용매

MeOH

반응 조건

후처리

1. 1
   기타The reaction contents
2. 2
   기타The reaction contents
3. 3
   여과were filtered through Celite (MeOH)
4. 4
   농축concentrated under vacuum

실험 절차

To a solution of phenylmethyl[((3S)-1-{(2S)-2-hydroxy-2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]carbamate (0.24 g, 0.56 mmole) in MeOH (50 mL) was added Pd(OH)2 (100 mg). The reaction contents were placed under a balloon of H2 and stirred for 18 hours. The reaction contents were filtered through Celite (MeOH) and concentrated under vacuum to give the title compound (0.16 g, 98%) as a light yellow oil: LC-MS (ES) m/e 303 (M+H)+.

출처