반응 #725916

반응 방정식

(4-Aminophenoxy)acetic acid methyl ester

(4-Nitro-phenoxy)-acetic acid-2-hydroxy-ethyl ester

→

46

수율 22.8%

(4-Amino-phenoxy)-acetic acid 2-hydroxy-ethyl ester

수율 22.8%

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타The catalyst was removed by filtration, ethyl acetate
2. 2
   workup.DISTILLATIONwas distilled off
3. 3
   workup.ADDITIONhexane was added
4. 4
   여과The solid product was filtered
5. 5
   기타dried

실험 절차

(4-Aminophenoxy)acetic acid methyl ester 41 (1 g, 4.15 mmol) was dissolved in ethyl acetate in a pressure vessel, palladium on carbon (5%, 0.5 g) was added and the mixture was stirred under an atmosphere of hydrogen (0.5 Kg) for one hour. The catalyst was removed by filtration, ethyl acetate was distilled off and hexane was added. The solid product was filtered and dried to give pure 46 (0.2 g, 22.8%) as a brown powder. M.p: 104-106.3° C.

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