반응 #725911

반응 방정식

methyl (4-nitrophenoxy)acetate

→

40

수율 92.1%

(4-Nitro phenoxy) acetic acid

수율 92.1%

용매

HCl

반응 조건

후처리

1. 1
   온도was refluxed for 8 hours
2. 2
   여과Crude 40 was filtered
3. 3
   기타dried
4. 4
   기타recrystallised from a mixture of ethyl acetate:hexane (1:5)

실험 절차

A mixture of methyl (4-nitrophenoxy)acetate 31 (100 g, 474 mmol) and concentrated HCl (1000 ml) was refluxed for 8 hours. The reaction mass was cooled to room temp. Crude 40 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 40 (86 g, 92.1%) as a white shining powder. M.p: 186-188.5° C.

출처