반응 #725908

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6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester

ethylene glycol

→

37

수율 84.0%

6-[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-hexanoic acid methyl ester

수율 84.0%

용매

Water

반응 조건

후처리

1. 1
   기타rose to 46° C
2. 2
   여과crude 37 was filtered
3. 3
   기타dried
4. 4
   기타recrystallised from toluene

실험 절차

6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester 36 (15 g, 57 mmol) was added to ethylene glycol (50 ml) at room temperature. The reaction was exothermic and the temperature rose to 46° C. The reaction mixture was allowed to cool to room temperature and later stirred at room temperature for 16 hours. Water (150 ml) was added and crude 37 was filtered, dried and recrystallised from toluene to get pure 37 (12 g, 84%) as a white powder. M.p: 69.5-71.5° C.

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