반응 #725902

반응 방정식

(4-Isocyanato-phenoxy)-acetic acid methyl ester

ethylene glycol

→

29

수율 82.9%

[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-acetic acid methyl ester

수율 82.9%

용매

Water

반응 조건

후처리

1. 1
   여과crude 29 was filtered
2. 2
   기타dried
3. 3
   기타purified by column chromatography on silica gel

실험 절차

(4-Isocyanato-phenoxy)-acetic acid methyl ester 28 (15 g, 72.46 mmol) was added to ethylene glycol (30 ml) at room temperature. The reaction was exothermic and the temperature raised to 42° C. Later the reaction mixture was stirred at room temperature for 16 hours. Water (100 ml) was added and crude 29 was filtered, dried and purified by column chromatography on silica gel using chloroform as eluant to get pure 29 (16.17 g, 82.9%) as a off-white powder. M.p: 85.5-87.5° C.

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