반응 #725899

반응 방정식

4-aminophenol

sodium bicarbonate

benzyloxy acetyl chloride

→

26

수율 48.9%

2-Benzyloxy-N-(4-hydroxy-phenyl)-acetamide

수율 48.9%

용매

acetone

반응 조건

후처리

1. 1
   여과The solids were filtered off
2. 2
   workup.ADDITIONcold water (500 ml) was added
3. 3
   추출Crude 26 was extracted into chloroform
4. 4
   세척washed with 5% sodium bicarbonate solution (2×100 ml), water (2×100 ml)
5. 5
   건조dried over sodium sulphate
6. 6
   workup.DISTILLATIONdistilled
7. 7
   기타The crude 26 was purified by column chromatography on silica gel

실험 절차

To mixture of 4-aminophenol (20 g, 183.2 mmol) and sodium bicarbonate (17 grams, 202 mmol) in acetone (150 ml) at 0° C. was added benzyloxy acetyl chloride (40 g, 216.8 mmol) drop wise, followed by stirring at room temperature for 20 hours. The solids were filtered off, and cold water (500 ml) was added. Crude 26 was extracted into chloroform, washed with 5% sodium bicarbonate solution (2×100 ml), water (2×100 ml), dried over sodium sulphate and distilled. The crude 26 was purified by column chromatography on silica gel using chloroform as eluant to get pure 26 (23 g, 48.9%) as a light orange syrup.

출처