반응 #725897

반응 방정식

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester

→

23

수율 71.1%

[2-(4-Amino-phenoxy)-ethoxy]-acetic acid methyl ester

수율 71.1%

용매

ethyl acetate

반응 조건

후처리

1. 1
   여과The catalyst was filtered
2. 2
   농축the filtrate concentrated
3. 3
   workup.ADDITIONhexane (3 ml) added
4. 4
   여과the solid filtered

실험 절차

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester 22 (1 g, 3.9 mmol) was dissolved in anhydrous ethyl acetate (20 ml), palladium carbon (10%, 0.1 g) added and the mixture stirred under an atmosphere of hydrogen using balloon for 30 minutes. The catalyst was filtered, the filtrate concentrated, hexane (3 ml) added, and the solid filtered to give 23 (625 mg, 70.9%) as a light brown powder. The melting point was found to be 51-52.5° C. The structure was confirmed with IR and NMR.

출처