반응 #72564

반응 방정식

2-bromo-1-(4-chloro-phenyl)-ethanone

potassium formate

→

title product

1-(4-Chloro-phenyl)-2-hydroxy-ethanone

용매

MeOH

반응 조건

후처리

1. 1
   온도at reflux for 3 hours
2. 2
   workup.ADDITIONThe reaction mixture is poured
3. 3
   기타onto crushed ice
4. 4
   기타The solid formed
5. 5
   여과is filtered off
6. 6
   세척washed with cold MeOH
7. 7
   기타dried in vacuo

실험 절차

A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (100 mmoles) and potassium formate (130 mmoles) in MeOH (100 ml) is stirred at reflux for 3 hours. The reaction mixture is poured onto crushed ice. The solid formed is filtered off, washed with cold MeOH and then dried in vacuo to yield the title product, which is used directly in the next Step.

출처