반응 #72528
ord-ac96ec0ecba344c39e16f6c953d0cc35
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도The solution is cooled to 0° C.
- 2추출After extraction with DCM
- 3세척the organic phases are washed with water and with saturated aqueous NaCl solution
- 4건조dried over sodium sulphate
- 5여과filtered
- 6기타evaporated to dryness
실험 절차
To a solution of morpholine (22 mmoles) in acetic acid (10 ml) there is added pyrrole (20 mmoles) dropwise at 0° C. Formaldehyde (37% aq., 20 mmoles) is then added dropwise. The reaction mixture is stirred for 2 hours at ambient temperature. The solution is cooled to 0° C. and is brought to alkaline pH (10-11) using 20% aqueous NaOH solution. After extraction with DCM, the organic phases are washed with water and with saturated aqueous NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness to yield the title product in the form of a white solid which is used directly in the next Step.