반응 #724399

반응 방정식

methyl 2,5-dihydroxybenzoate

imidazole

t-butyldimethylsilyl chloride

→

methyl 2-hydroxy-5-(t-butyldimethylsilyloxy)benzoate

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   추출extract with water
2. 2
   건조Dry the organic layer over MgSO4
3. 3
   여과filter
4. 4
   기타evaporate in vacuo

실험 절차

Combine methyl 2,5-dihydroxybenzoate (8.45 g, 50.2 mmol), imidazole (4.1 g, 60.3 mmol), and t-butyldimethylsilyl chloride (9.09 g, 60.3 mmol) in dichloromethane (100 mL). After 30 minutes, dilute the reaction mixture with dichloromethane (100 mL) and extract with water. Dry the organic layer over MgSO4, filter and evaporate in vacuo to give methyl 2-hydroxy-5-(t-butyldimethylsilyloxy)benzoate.

출처