반응 #724316

반응 방정식

hydrochloric acid

methyl 3-methoxy-4,5-dihydroxybenzoate

potassium carbonate

dibromoethane

→

methyl 3-methoxy-4,5-ethylenedioxybenzoate

용매

water

acetone

반응 조건

후처리

1. 1
   온도Heat to reflux
2. 2
   온도cool in an ice bath
3. 3
   추출extract three times with ethyl acetate
4. 4
   추출extract with brine
5. 5
   건조Dry over-MgSO4
6. 6
   여과filter
7. 7
   농축concentrate in vacuo

실험 절차

Combine methyl 3-methoxy-4,5-dihydroxybenzoate (0.5 g, 2.5 mmol) and potassium carbonate (1.74 g, 12.65 mmol) in acetone (25 mL). Add dibromoethane (2.37 g, 12.65 mmol). Heat to reflux. After 24 hours, cool in an ice bath, acidify with a 1 M aqueous hydrochloric acid solution (35 mL), add water (25 mL), and extract three times with ethyl acetate. Combine the organic layers and extract with brine. Dry over-MgSO4, filter, and concentrate in vacuo to give methyl 3-methoxy-4,5-ethylenedioxybenzoate.

출처