반응 #7240

반응 방정식

2-(hydroxymethyl)-3-methylpyridine

→

3-methylpyridine-2-carboxaldehyde

수율 64.0%

용매

CH2Cl2

반응 조건

후처리

1. 1
   여과then filtered through celite
2. 2
   농축The filtrate was concentrated

실험 절차

To a stirred solution of 2-(hydroxymethyl)-3-methylpyridine (1.08 g, 8.77 mmol) in dry CH2Cl2 (45 mL) at room temperature was added MnO2 (8.09 g, 79.1 mmol). The mixture was stirred for 21 hrs then filtered through celite. The filtrate was concentrated to give 0.68 g (64%) of 3-methylpyridine-2-carboxaldehyde. 1H NMR (CDCl3) □ 2.66 (s, 3H), 7.39 (dd, 1H, J=8.3, 4.3 Hz), 7.63 (d, 1H, J=7.9 Hz), 8.66 (d, 1H, J=3.3 Hz), 10.19 (s, 1H). This was used without further purification.

출처