반응 #723008

반응 방정식

(+/−)-cis-1,2-dimethoxy-4-(2-nitrocyclohexyl)benzene

hydrazine hydrate

→

(+/−)-cis-1,2-dimethoxy-4-(2-aminocyclohexyl)benzene

용매

methanol

반응 조건

후처리

1. 1
   여과filtered
2. 2
   농축the filtrate is concentrated
3. 3
   기타the residue is chromatographed over silica gel using
4. 4
   workup.ADDITIONa mixture of toluene/ethyl acetate/triethylamine=4/2/0.5

실험 절차

8.5 g of (+/−)-cis-1,2-dimethoxy-4-(2-nitrocyclohexyl)benzene are dissolved in 400 ml of methanol and, at RT, admixed in portions with 7 ml of hydrazine hydrate and 2.5 g of Raney nickel over a period of 8 h. The reaction mixture is stirred at RT overnight and then filtered, the filtrate is concentrated and the residue is chromatographed over silica gel using a mixture of toluene/ethyl acetate/triethylamine=4/2/0.5.

출처