반응 #722450

반응 방정식

Hydrazine hydrate

4-oxo-4-(2-oxocyclohexyl)-n-butyric acid

→

3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid

수율 97.1%

용매

ethanol

반응 조건

후처리

1. 1
   온도the mixture was refluxed for 1 hour
2. 2
   기타After the completion of the reaction
3. 3
   온도the reaction mixture was cooled
4. 4
   여과the precitated crystals were collected by filtration

실험 절차

Hydrazine hydrate (1.1 g) was added to a solution (40 ml) of 4-oxo-4-(2-oxocyclohexyl)-n-butyric acid (4.1 g) in ethanol and the mixture was refluxed for 1 hour. After the completion of the reaction, the reaction mixture was cooled and the precitated crystals were collected by filtration to give 3.9 g of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid, m.p. 135-136° C.

출처