반응 #72245

반응 방정식

HOBT

methyl cis(±)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methoxybenzoate

Methyl cis(±)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methoxybenzoate

4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

WSC hydrochloride

→

title compound

수율 58.2%

Methyl cis(±)-5-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methoxybenzoate

수율 58.2%

용매

dichloromethane

DMA

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실험 절차

The same operation as in Example (1g) was performed using methyl cis(±)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methoxybenzoate obtained in Example (258b) (about 0.08 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained in Example (1d) (14 mg, 0.08 mmol), WSC hydrochloride (52 mg, 0.27 mmol), HOBT (18 mg, 0.14 mmol), dichloromethane (1 mL) and DMA (1 mL), to obtain 21 mg of the title compound as a colorless oily substance (57%).

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