반응 #72242

반응 방정식

HOBT

methyl cis(±)-3-(4-amino-3-methoxypiperidin-1-yl)-5-methoxybenzoate

Methyl cis(±)-3-(4-amino-3-methoxypiperidin-1-yl)-5-methoxybenzoate

4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

WSC hydrochloride

→

title compound

수율 88.0%

Methyl cis(±)-3-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methoxybenzoate

수율 88.0%

용매

dichloromethane

DMA

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실험 절차

The same operation as in Example (1g) was performed using methyl cis(±)-3-(4-amino-3-methoxypiperidin-1-yl)-5-methoxybenzoate obtained in Example (257c) (about 0.25 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained in Example (1d) (48 mg, 0.22 mmol), WSC hydrochloride (139 mg, 0.73 mmol), HOBT (49 mg, 0.36 mmol), dichloromethane (2 mL) and DMA (2 mL), to obtain 87 mg of the title compound (88%).

출처