반응 #7221

반응 방정식

N-benzimidazolyl-1,2-propanediol

sodium periodate

→

2-(benzimidazol-1-yl)-ethanal

수율 41.2%

용매

water

반응 조건

후처리

1. 1
   추출The solution was then extracted with dichloromethane
2. 2
   건조dried (MgSO4)
3. 3
   여과filtered
4. 4
   농축concentrated

실험 절차

The intermediate, N-benzimidazolyl-1,2-propanediol (0.66 g, 3.4 mmol) from above was dissolved in water (25 mL) and treated with sodium periodate (0.88 g, 4.1 mmol) with stirring for 1.5 hours. The solution was then extracted with dichloromethane, dried (MgSO4), filtered and concentrated to yield 2-(benzimidazol-1-yl)-ethanal (0.22 g, 1.4 mmol) which was used immediately without further purification in the next reaction.

출처