반응 #72197

반응 방정식

ammonia

cis(±)-1-(diphenylmethyl)-2-ethylazetidin-3-yl methanesulfonate

cis(±)-1-(Diphenylmethyl)-2-ethylazetidin-3-yl methanesulfonate

→

title compound

cis(±)-1-(Diphenylmethyl)-2-ethylazetidin-3-amine

용매

isopropanol

반응 조건

후처리

1. 1
   농축The reaction solution was concentrated under reduced pressure
2. 2
   workup.ADDITIONThen, saturated aqueous sodium bicarbonate solution was added to the resulting residue
3. 3
   추출followed by extraction with chloroform
4. 4
   건조The combined organic layers were dried over anhydrous magnesium sulfate
5. 5
   여과filtered
6. 6
   농축Thereafter, the filtrate was concentrated under reduced pressure

실험 절차

28% aqueous ammonia (1.2 ml) was added to a solution of cis(±)-1-(diphenylmethyl)-2-ethylazetidin-3-yl methanesulfonate obtained in Example (235c) (315 mg, 0.91 mmol) in isopropanol (2 mL), and the mixture was stirred at 70° C. for four hours. The reaction solution was concentrated under reduced pressure. Then, saturated aqueous sodium bicarbonate solution was added to the resulting residue, followed by extraction with chloroform. The combined organic layers were dried over anhydrous magnesium sulfate and filtered. Thereafter, the filtrate was concentrated under reduced pressure to obtain 206 mg of the title compound as a pale yellow oily substance (85%).

출처