반응 #72189

반응 방정식

hydrochloric acid ethyl acetate

tert-butyl 3-({[(benzyloxy)carbonyl]amino}methyl)azetidine-1-carboxylate

→

3-({[(benzyloxy)carbonyl]amino}methyl)azetidine hydrochloride

수율 100.0%

용매

1,4-dioxane methanol

반응 조건

후처리

1. 1
   농축The reaction solution was concentrated

실험 절차

A 4 N hydrochloric acid/ethyl acetate solution (3.90 mL, 15.6 mmol) was added to a solution of tert-butyl 3-({[(benzyloxy)carbonyl]amino}methyl)azetidine-1-carboxylate obtained in Example (233a) (560 mg, 1.75 mmol) in 1,4-dioxane/methanol (8 mL/8 mL), and the mixture was stirred at room temperature for 4.5 hours. The reaction solution was concentrated to obtain 448 mg of 3-({[(benzyloxy)carbonyl]amino}methyl)azetidine hydrochloride (100%).

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