반응 #721742

반응 방정식

ethyl (2-fluoro-4-chloro-phenyl)malonate

methylhydrazine

2-propanol

→

1-Methyl-5-hydroxy-3-(2-fluoro-4-chlorophenyl)pyrazole

반응 조건

후처리

1. 1
   온도at reflux for about 48 hours
2. 2
   농축After this time the reaction mixture was concentrated under reduced pressure to a residue
3. 3
   여과filtered
4. 4
   기타to collect 27.0 grams of 1-methyl-2-hydroxy-3-(2-fluoro-4-chlorophenyl)pyrazole

실험 절차

A stirred solution of 44.0 grams (0.18 mole) of ethyl (2-fluoro-4-chloro-phenyl)malonate and 9.6 grams (0.24 mole) of methylhydrazine in 150 mL of 2-propanol was heated at reflux for about 48 hours. After this time the reaction mixture was concentrated under reduced pressure to a residue. The residue was slurred in 80 mL of methylene chloride and filtered to collect 27.0 grams of 1-methyl-2-hydroxy-3-(2-fluoro-4-chlorophenyl)pyrazole.

출처