반응 #72110

반응 방정식

ethyl 3-(4-tert-butoxycarbonylaminocyclohex-1-enyl)benzoate

→

title compound

수율 57.8%

Ethyl 3-(4-aminocyclohex-1-enyl)benzoate

수율 57.8%

용매

hydrochloric acid 1,4-dioxane

반응 조건

후처리

1. 1
   기타the solvent was evaporated under reduced pressure
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in methanol
3. 3
   workup.ADDITIONAmberlite IRA-400(Cl) ion exchange resin (20 g) was added
4. 4
   workup.STIRRINGthe mixture was stirred at room temperature for one hour
5. 5
   여과Amberlite was filtered off
6. 6
   농축the solution was concentrated under reduced pressure

실험 절차

A 4 N hydrochloric acid/1,4-dioxane solution (20 mL) was added to ethyl 3-(4-tert-butoxycarbonylaminocyclohex-1-enyl)benzoate obtained in Example (195b) (510 mg, 1.48 mmol). The mixture was stirred at room temperature for one hour, and the solvent was evaporated under reduced pressure. The resulting residue was dissolved in methanol. Amberlite IRA-400(Cl) ion exchange resin (20 g) was added, and the mixture was stirred at room temperature for one hour. Amberlite was filtered off, and then the solution was concentrated under reduced pressure to obtain 210 mg of the title compound as a colorless oily substance.

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