반응 #72108

반응 방정식

4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid

1-hydroxybenzotriazole

1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride

triethylamine

Ethyl cis-3-(4-aminocyclohexyl)benzoate

→

title compound

수율 53.8%

Ethyl cis-3-{4-[(4-chloro-5-ethyl-1H-imidazole-2-carbonyl)amino]cyclohexyl}benzoate

수율 53.8%

용매

ethyl acetate

N,N-dimethylacetamide dichloromethane

1/1

water TFA

반응 조건

후처리

1. 1
   세척washed with brine
2. 2
   건조dried over magnesium sulfate
3. 3
   기타The solvent was evaporated under reduced pressure
4. 4
   기타The resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=1/1)

실험 절차

Ethyl cis-3-(4-aminocyclohexyl)benzoate obtained in Example (194a) (57 mg, 0.23 mmol) was dissolved in a mixed solution of N,N-dimethylacetamide/dichloromethane=1/1 (10 mL). 4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid (described in Example 1d, 60 mg, 0.345 mmol), 1-hydroxybenzotriazole (64 mg, 0.472 mmol), 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (90 mg, 0.472 mmol) and triethylamine (66 μL, 0.472 mmol) were added, and the mixture was stirred at room temperature overnight. The reaction solution was diluted with ethyl acetate, washed with brine, and then dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=1/1) to obtain 50 mg of the title compound as a white solid (53%).

출처