반응 #72107

ord-40f9be66b7124c7399589eccafc69b98

반응 방정식

CCOC(=O)c1cccc([C@H]2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)CC2)c1
ethyl trans-3-{4-[(4-chloro-5-ethyl-1H-imidazole-2-carbonyl)amino]cyclohexyl}benzoate
CCOC(=O)c1cccc([C@H]2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)CC2)c1
Ethyl trans-3-{4-[(4-chloro-5-ethyl-1H-imidazole-2-carbonyl)amino]cyclohexyl}benzoate
O.[Li+].[OH-]
lithium hydroxide monohydrate
→
CCc1[nH]c(C(=O)N[C@H]2CC[C@H](c3cccc(C(=O)O)c3)CC2)nc1Cl
title compound
수율 58.0%
CCc1[nH]c(C(=O)N[C@H]2CC[C@H](c3cccc(C(=O)O)c3)CC2)nc1Cl
trans-3-{4-[(4-Chloro-5-ethyl-1H-imidazole-2-carbonyl)amino]cyclohexyl}benzoic acid
수율 58.0%

반응물

CCOC(=O)c1cccc([C@H]2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)CC2)c1
ethyl trans-3-{4-[(4-chloro-5-ethyl-1H-imidazole-2-carbonyl)amino]cyclohexyl}benzoate
CCOC(=O)c1cccc([C@H]2CC[C@H](NC(=O)c3nc(Cl)c(CC)[nH]3)CC2)c1
Ethyl trans-3-{4-[(4-chloro-5-ethyl-1H-imidazole-2-carbonyl)amino]cyclohexyl}benzoate
O.[Li+].[OH-]
lithium hydroxide monohydrate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The same operation as in Example (1i) was performed using ethyl trans-3-{4-[(4-chloro-5-ethyl-1H-imidazole-2-carbonyl)amino]cyclohexyl}benzoate obtained in Example (193b) (43 mg, 0.106 mmol) and lithium hydroxide monohydrate (44 mg, 1.06 mmol), to obtain 23 mg of the title compound as a white solid (58%).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08536197B2uspto-grants-2013_09