반응 #721067
ord-58511c015e8f4a248fc313b19c39a685
반응 방정식
반응 조건
온도
0°CELSIUS
상세 조건
See reaction.notes.procedure_details.
실험 절차
To a solution of 1-diphenylmethylazetidin-3-ol (359 mg, 1.5 mmol) in DMF (1 mL) at 0° C. under nitrogen was added NaH (60% in oil, 66 mg, 1.65 mmol). The suspension was stirred for 0.5 h at 0° C. then treated with 2-(chloromethyl)thiophene (464 mg, 3.5 mmol; which may be prepared as described in Step 1) dissolved in DMF (2 mL).