반응 #72101

반응 방정식

tert-butyl 4-benzyloxycarbonylaminopiperidine-1-carboxylate

tert-Butyl 4-benzyloxycarbonylaminopiperidine-1-carboxylate

→

title compound

수율 86.5%

Benzyl piperidin-4-yl-carbamate

수율 86.5%

용매

hydrochloric acid 1,4-dioxane

반응 조건

후처리

1. 1
   기타the solvent was evaporated under reduced pressure
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in methanol
3. 3
   workup.ADDITIONAmberlite IRA-400(Cl) ion exchange resin (20 g) was added
4. 4
   workup.STIRRINGthe mixture was stirred at room temperature for one hour
5. 5
   여과Amberlite was filtered off
6. 6
   농축the solution was concentrated under reduced pressure

실험 절차

A 4 N hydrochloric acid/1,4-dioxane solution (20 mL) was added to tert-butyl 4-benzyloxycarbonylaminopiperidine-1-carboxylate obtained in Example (192a) (1.5 g, 4.49 mmol). The mixture was stirred at room temperature for one hour, and the solvent was evaporated under reduced pressure. The resulting residue was dissolved in methanol. Amberlite IRA-400(Cl) ion exchange resin (20 g) was added, and the mixture was stirred at room temperature for one hour. Amberlite was filtered off, and then the solution was concentrated under reduced pressure to obtain 910 mg of the title compound as a colorless oily substance.

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