반응 #72092

반응 방정식

hydrochloric acid

Sodium methoxide

Methyl acetoacetate

benzyl cis(±)-[1-(chloroacetyl)-3-methoxypiperidin-4-yl]carbamate

Benzyl cis(±)-[1-(chloroacetyl)-3-methoxypiperidin-4-yl]carbamate

→

title compound

Methyl cis(±)-2-acetyl-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-oxobutanoate

용매

ethyl acetate

methanol

methanol

반응 조건

후처리

1. 1
   workup.ADDITIONThe solution was added to the reaction solution
2. 2
   workup.STIRRINGthe mixture was stirred at 70° C. overnight
3. 3
   세척washed with brine
4. 4
   건조dried over anhydrous sodium sulfate
5. 5
   농축concentration under reduced pressure

실험 절차

Methyl acetoacetate (510 mg, 4.4 mmol) was dissolved in methanol (15 ml). Sodium methoxide (210 mg, 3.9 mmol) was added, and the mixture was stirred at room temperature for 30 minutes. Further, benzyl cis(±)-[1-(chloroacetyl)-3-methoxypiperidin-4-yl]carbamate obtained in Example (188a) was dissolved in methanol (10 ml). The solution was added to the reaction solution, and the mixture was stirred at 70° C. overnight. The reaction solution was diluted with ethyl acetate, neutralized with 1 N hydrochloric acid, washed with brine, and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, the title compound was obtained. The resulting compound was used for the next reaction without purification.

출처