반응 #72079

반응 방정식

Ethyl 6-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethyl-1-benzothiophene-2-carboxylate

lithium hydroxide

→

title compound

수율 87.7%

6-{[(4-Chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethyl-1-benzothiophene-2-carboxylic acid

수율 87.7%

용매

THF

methanol

반응 조건

후처리

1. 1
   기타The organic solvent was evaporated under reduced pressure
2. 2
   여과The resulting solid was collected by filtration
3. 3
   세척washed with distilled water and ethyl acetate
4. 4
   기타dried under reduced pressure at 45° C.

실험 절차

Ethyl 6-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethyl-1-benzothiophene-2-carboxylate obtained in Example (183f) (49 mg) was dissolved in methanol (2 ml) and THF (2 ml). A 2 N aqueous lithium hydroxide solution (2 ml) was added, and the mixture was stirred at 50° C. for 30 minutes. The organic solvent was evaporated under reduced pressure, followed by neutralization with 1 N hydrochloric acid. The resulting solid was collected by filtration, washed with distilled water and ethyl acetate, and dried under reduced pressure at 45° C. to obtain 40 mg of the title compound as a solid.

출처