반응 #720552

반응 방정식

N-(2-chloro-5-fluoropyrimidin-4-yl)-octahydro-5,5-dimethylindolizin-7-amine

5-amino-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

→

NH3 MeOH

수율 1.0%

5-(5-fluoro-4-(octahydro-5,5-dimethylindolizin-7-ylamino)pyrimidin-2-ylamino)-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

수율 150.9%

용매

IPA

반응 조건

후처리

1. 1
   온도After cooling to ambient temperature
2. 2
   농축the crude mixture was concentrated to dryness
3. 3
   기타The layers were separated
4. 4
   세척The organic layer was washed with 1N NaOH (×2)
5. 5
   건조dried over Na2SO4
6. 6
   여과filtered
7. 7
   농축concentrated to dryness
8. 8
   기타The crude product was purified by flash chromatography
9. 9
   세척eluted with DCM

실험 절차

A mixture of N-(2-chloro-5-fluoropyrimidin-4-yl)-octahydro-5,5-dimethylindolizin-7-amine (Racemic, single diastereomer; 150 mg, 0.502 mmol, 1 equiv), 5-amino-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile (153 mg, 0.703 mmol, 1.4 equiv), and PTSA monohydrate (95 mg, 0.502 mmol, 1 equiv) in IPA (5 ml) were heated to 70° C. for 3 days. After cooling to ambient temperature, the crude mixture was concentrated to dryness and taken in water, EtOAc, and 1N NaOH. The layers were separated. The organic layer was washed with 1N NaOH (×2), dried over Na2SO4, filtered, and concentrated to dryness. The crude product was purified by flash chromatography and eluted with DCM:2M NH3/MeOH=100:0 to 96:4 using 1% 2M NH3/MeOH increments to give compound 5-(5-fluoro-4-(octahydro-5,5-dimethylindolizin-7-ylamino)pyrimidin-2-ylamino)-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile (Compound 41)(Racemic, single diastereomer; 182 mg, 76%) as a solid.

출처