반응 #720533

반응 방정식

(8aR)-2,2-difluoro-octahydro-5,5-dimethyl-N—((S)-1-phenylethyl)indolizin-7-amine hydrogen chloride

hydrogen

→

(8aR)-2,2-difluoro-octahydro-5,5-dimethylindolizin-7-amine hydrogen chloride

용매

MeOH

반응 조건

후처리

1. 1
   workup.ADDITIONwas added at 16 hours and 24 hours
2. 2
   기타Solid was removed by filtration through a short Celite column
3. 3
   세척washing with MeOH
4. 4
   기타Filtrate was collected
5. 5
   기타solvent was removed in vacuo

실험 절차

A MeOH (20 ml) solution of (8aR)-2,2-difluoro-octahydro-5,5-dimethyl-N—((S)-1-phenylethyl)indolizin-7-amine hydrogen chloride and Pd(OH)2—C (20% on activated carbon, 50% wet, 0.2 g) was hydrogenated in a Parr flask under 45 psi of hydrogen. Additional Pd(OH)2—C was added (˜0.2 g) was added at 16 hours and 24 hours, and the reaction went to completion at 39 hours monitored by LC-MS. Solid was removed by filtration through a short Celite column, washing with MeOH. Filtrate was collected, solvent was removed in vacuo. Compound (8aR)-2,2-difluoro-octahydro-5,5-dimethylindolizin-7-amine hydrogen chloride was obtained as an off-white solid and was used directly in next reaction: 0.56 g; LRMS] (M+H) ink 204.99.

출처