반응 #72023

반응 방정식

Water

Triethylamine

1,1′-carbonylbis-1H-imidazole

L-proline methyl ester hydrochloride

→

title compound

수율 100.0%

1-(1H-Imidazol-1-ylcarbonyl)-L-proline methyl ester

수율 100.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   추출followed by extraction with dichloromethane
2. 2
   세척Then, the organic layer was washed with brine
3. 3
   건조dried over anhydrous sodium sulfate
4. 4
   농축concentration under reduced pressure

실험 절차

L-proline methyl ester hydrochloride (0.300 g, 1.81 mmol) was dissolved in dichloromethane (5 ml). Triethylamine (0.202 g, 1.99 mmol) and 1,1′-carbonylbis-1H-imidazole (0.352 g, 2.17 mmol) were added, and the mixture was stirred at room temperature for five days. Water was added to the reaction solution, followed by extraction with dichloromethane. Then, the organic layer was washed with brine and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, 0.404g of the title compound was obtained as a colorless oily substance (100%).

출처