반응 #720080

반응 방정식

THF

4-chloro-6-ethyl-5-iodo-pyrimidine

ethyl-amine

triethylamine

→

desired compound

[5-(4-Chloro-6-ethyl-pyrimidin-5-ylethynyl)-pyridin-2-yl]-ethyl-amine

반응 조건

후처리

1. 1
   기타The title compound is synthesized

실험 절차

The title compound is synthesized according to general procedure GP2 starting from 4-chloro-6-ethyl-5-iodo-pyrimidine using 5-Ethynyl-pyridin-2-yl)-ethyl-amine (A-28), CuI, bis-(triphenyl-phoshine)palladium(II) chloride, triethylamine in THF. After work-up the desired compound is obtained in good yield and acceptable purity.

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