반응 #71968

반응 방정식

3-(2,2-difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-one

3-(2,2-Difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-one

benzylamine

sodium (triacetoxy)borohydride

→

title compound

수율 79.2%

cis(±)-N-benzyl-3-(2,2-difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-amine

수율 79.2%

용매

1,2-dichloroethane

반응 조건

후처리

1. 1
   기타The resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=4/1, 1/1, 1/3, 0/1)

실험 절차

The same operation as in Example (90c) was performed using 3-(2,2-difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-one obtained in Example (121c) (1.1 g, 4 mmol), benzylamine (0.54 g, 5 mmol), sodium (triacetoxy)borohydride (0.85 g, 6 mmol) and 1,2-dichloroethane (15 mL). The resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=4/1, 1/1, 1/3, 0/1) to obtain 1.16 g of the title compound as a yellow oily substance (79%).

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