반응 #71929

반응 방정식

THF

tert-butyl cis(±)-4-amino-3-ethoxypiperidine-1-carboxylate

tert-Butyl cis(±)-4-amino-3-ethoxypiperidine-1-carboxylate

sodium bicarbonate

benzyl chloroformate

→

title compound

수율 100.6%

tert-Butyl cis(±)-4-{[(benzyloxy)carbonyl]amino}-3-ethoxypiperidine-1-carboxylate

수율 100.6%

용매

water

반응 조건

후처리

1. 1
   기타The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/4, 1/2, 1/1)

실험 절차

The same operation as in Example (103a) was performed using tert-butyl cis(±)-4-amino-3-ethoxypiperidine-1-carboxylate obtained in Example (112d) (2.28 g, 11.4 mmol), sodium bicarbonate (1.26 g, 15 mmol), benzyl chloroformate (2.69 g, 15 mmol), THF (15 mL) and water (15 mL). The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/4, 1/2, 1/1) to obtain 4.34 g of the title compound as a colorless solid (100%).

출처