반응 #719062

반응 방정식

2-(1-Benzyl-1H-tetrazol-5-yl)-3-methoxyphenylamine

Intermediate 13

2-(1-Benzyl-1H-tetrazol-5-yl)-3-methoxyphenylamine

Benzenesulfonyl chloride

→

title compound

수율 63.8%

N-[2-(1-Benzyl-1H-tetrazol-5-yl)-3-methoxyphenyl]-benzene sulfonamide

수율 63.8%

용매

DCM

pyridine

DCM

반응 조건

후처리

1. 1
   세척washed with 1N hydrochloric acid
2. 2
   건조dried with magnesium sulfate
3. 3
   여과filtered
4. 4
   기타The filtrate was evaporated to dryness
5. 5
   기타the residue was purified by flash chromatography on silica
6. 6
   세척eluting with a mixture of DCM and methanol
7. 7
   workup.ADDITIONThe fractions containing the desired product
8. 8
   기타evaporated

실험 절차

2-(1-Benzyl-1H-tetrazol-5-yl)-3-methoxyphenylamine (Intermediate 13, 0.115 g) was dissolved in pyridine (0.16 mL) and DCM (2 mL). Benzenesulfonyl chloride (0.08 g) was added and the mixture was stirred overnight. The reaction mixture was diluted with DCM and washed with 1N hydrochloric acid, dried with magnesium sulfate and filtered. The filtrate was evaporated to dryness and the residue was purified by flash chromatography on silica, eluting with a mixture of DCM and methanol. The fractions containing the desired product were combined and evaporated to give the title compound as a colorless solid (0.11 g).

출처