반응 #71893

반응 방정식

butyl 2-oxobutanoate

bromine

→

title compound

수율 114.9%

Butyl 3-bromo-2-oxobutanoate

수율 114.9%

용매

dichloromethane

반응 조건

후처리

1. 1
   세척the reaction solution was washed with aqueous sodium bicarbonate solution
2. 2
   세척washed with brine
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated under reduced pressure

실험 절차

A solution of butyl 2-oxobutanoate (described in Patent; IMPERIAL CHEMICAL INDUSTRIES PLC; Publ.: EP 375457 B1 (1994/03/16), Appl.: EP 1989-313521 (1989/12/22), 14g, 88.6 mmol) in dichloromethane (100 mL) was cooled to 0° C., and bromine (4 mL, 80 mmol) was added over 15 minutes. Following stirring at room temperature for 30 minutes, the reaction solution was washed with aqueous sodium bicarbonate solution, washed with brine, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain 21.8 g of the title compound as a colorless liquid (100%).

출처