반응 #7189

반응 방정식

1,2-Phenylenediamine

3-chloropropionic acid

→

title compound

수율 32.3%

2-(2-Chloroethyl)-1H-benzimidazole

수율 32.3%

용매

HCl

반응 조건

실험 절차

A mixture of 1,2-Phenylenediamine (1.3 g, 12.0 mmol) and 3-chloropropionic acid (2.0 g, 18.5 mmol) were refluxed in 4N HCl (13 mL) for 16 hours to give the title compound as white solid (700 mg, 32%). 1H NMR (CD3OD) □ 3.35 (t, 2H, J=6.8 Hz), 4.00 (t, 2H, J=6.8 Hz), 7.18–7.25 (m, 2H), 7.49–7.55 (m, 2H); ES-MS m/z 181.0 (M+H).

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