반응 #71823

ord-381668cdb1d84770978843b0789c4efa

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타obtained by the method

실험 절차

The same operation as in Example (77d) was performed using ethyl cis(±)-2-(3-amino-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-benzothiazole-7-carboxylate obtained by the method described in Example (81e) (30 mg, 0.063 mmol), 1-pentanal (14 μL, 0.13 mmol) and sodium (triacetoxy)borohydride (120 mg, 0.57 mmol), to obtain 30.8 mg of the title compound as a colorless oily substance (90%).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08536197B2uspto-grants-2013_09