반응 #71791

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Benzyl cis(±)-[1-(1H-imidazol-1-ylthiocarbonyl)-3-methoxypiperidin-4-yl]-carbamate

ammonia methanol

→

title compound

수율 67.4%

Benzyl cis(±)-(1-carbamothioyl-3-methoxypiperidin-4-yl)-carbamate

수율 67.4%

용매

Brine

THF

반응 조건

후처리

1. 1
   추출followed by extraction with ethyl acetate
2. 2
   건조The organic layer was dried over anhydrous sodium sulfate
3. 3
   농축concentrated under reduced pressure
4. 4
   여과The precipitated solid was collected by filtration

실험 절차

Benzyl cis(±)-[1-(1H-imidazol-1-ylthiocarbonyl)-3-methoxypiperidin-4-yl]-carbamate obtained in Example (64a) (about 1.36 mmol) was dissolved in THF (2 mL). A 2 N ammonia/methanol solution (10 mL) was added, and the mixture was stirred for 42 hours. Brine was added to the reaction solution, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The precipitated solid was collected by filtration to obtain 296.5 mg of the title compound as a white solid (67%).

출처