반응 #71782

반응 방정식

WSC hydrochloride

tert-butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate

4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

HOBT

Example ( 1d )

4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid

→

title compound

수율 72.0%

tert-Butyl (3S,4R)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate

수율 72.0%

반응 조건

후처리

1. 1
   기타synthesized by the method

실험 절차

The same operation as in Example (1g) was performed using tert-butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate obtained in Example (56a) (224.4 mg, 0.96 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid synthesized by the method described in Example (1d) (140 mg, 0.80 mmol), WSC hydrochloride (440 mg, 2.29 mmol) and HOBT (110 mg, 0.81 mmol), to obtain 222.4 mg of the title compound as a white solid (72%).

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