반응 #71756

반응 방정식

tert-Butyl cis(±)-4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidine-1-carboxylate

hydrochloric acid ethyl acetate

→

Benzyl cis(±)-(3-methoxypiperidin-4-yl)-carbamate

용매

methanol

반응 조건

후처리

1. 1
   농축The reaction solution was concentrated under reduced pressure
2. 2
   workup.ADDITIONsaturated aqueous sodium bicarbonate solution was added
3. 3
   추출followed by extraction with THF
4. 4
   건조The organic layer was dried over anhydrous sodium sulfate
5. 5
   농축concentrated under reduced pressure
6. 6
   기타The resulting compound was used for the next reaction without purification

실험 절차

tert-Butyl cis(±)-4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidine-1-carboxylate obtained in Example (40a) (4.28 g, 11.7 mmol) was dissolved in methanol (20 mL). A 4 N hydrochloric acid/ethyl acetate solution (60 mL) was added, and the mixture was stirred at room temperature for 40 minutes. The reaction solution was concentrated under reduced pressure and then saturated aqueous sodium bicarbonate solution was added, followed by extraction with THF. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

출처