반응 #71745

반응 방정식

2,2,2-Trifluoro-1-(2-methyl-1,3-dithian-2-yl)ethanone

dimethoxyacetaldehyde

ammonia

NCS

→

2-(Dimethoxymethyl)-5-methyl-4-(trifluoromethyl)-1H-imidazole

용매

acetonitrile

반응 조건

후처리

1. 1
   workup.DISTILLATIONdistilled water (10 mL)
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 18 hours
3. 3
   여과The reaction solution was filtered through celite
4. 4
   농축concentrated under reduced pressure
5. 5
   기타The resulting compound was used for the next reaction without purification

실험 절차

NCS (870 mg, 6.51 mmol) and silver nitrate (1.48 g, 8.71 mmol) were dissolved in acetonitrile (40 mL) and distilled water (10 mL). 2,2,2-Trifluoro-1-(2-methyl-1,3-dithian-2-yl)ethanone obtained in Example (36a) (500 mg, 2.17 mmol) was added, and the mixture was stirred for 40 minutes. Thereafter, dimethoxyacetaldehyde (5.76 M aqueous solution, 0.4 mL, 23.0 mmol) and 28% aqueous ammonia (2 mL) were added, and the mixture was stirred at room temperature for 18 hours. The reaction solution was filtered through celite and then concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

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