반응 #71729

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WSC hydrochloride

tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate

Example ( 1e )

tert-Butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate

HOBT

4-bromo-5-ethyl-1H-imidazole-2-carboxylic acid

→

title compound

수율 92.0%

tert-Butyl cis(±)-4-{[(4-bromo-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate

수율 92.0%

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후처리

1. 1
   기타obtained by the method

실험 절차

The same operation as in Example (1g) was performed using tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate obtained by the method described in Example (1e) (0.39 g, 1.67 mmol), 4-bromo-5-ethyl-1H-imidazole-2-carboxylic acid obtained in Example (25b) (0.18 g, 0.82 mmol), WSC hydrochloride (0.49 g, 2.53 mmol) and HOBT (0.11 g, 0.84 mmol), to obtain 0.33 g of the title compound as a white solid (92%).

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