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Example ( 1d )

4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid

ethyl cis(±)-2-(4-amino-3-methoxypiperidin-1-yl)-1,3-thiazole-5-carboxylate

Example ( 5d )

Ethyl cis(±)-2-(4-amino-3-methoxypiperidin-1-yl)-1,3-thiazole-5-carboxylate

WSC hydrochloride

4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

→

title compound

수율 71.0%

Ethyl cis(±)-2-(4-{[(4-Chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-1,3-thiazole-5-carboxylate

수율 71.0%

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후처리

1. 1
   기타obtained by the method
2. 2
   기타obtained by the method

실험 절차

The same operation as in Example (1g) was performed using ethyl cis(±)-2-(4-amino-3-methoxypiperidin-1-yl)-1,3-thiazole-5-carboxylate obtained by the method described in Example (5d) (0.22 g, 0.77 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained by the method described in Example (1d) (85 mg, 0.49 mmol), WSC hydrochloride (0.56 g, 2.92 mmol) and DMAP (0.13 g, 1.02 mmol), to obtain 0.15 g of the title compound as a pale yellow solid (71%).

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