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WSC hydrochloride

tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate

Example ( 1e )

tert-Butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate

4,5-dibromoimidazole-2-carboxylic acid

→

title compound

수율 72.0%

tert-Butyl cis(±)-4-{[(4,5-dibromo-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate

수율 72.0%

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후처리

1. 1
   기타obtained by the method

실험 절차

The same operation as in Example (1g) was performed using tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate obtained by the method described in Example (1e) (300 mg, 1.30 mmol), 4,5-dibromoimidazole-2-carboxylic acid obtained in Example (2a) (300 mg, 1.11 mmol), WSC hydrochloride (460 mg, 2.40 mmol) and DMAP (50 mg, 0.41 mmol), to obtain 384 mg of the title compound as a white solid (72%).

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